Data supporting "Factors associated with brain damage in smoking-related diseases: Chronic Obstructive Pulmonary Disease (COPD) and coronary artery disease"
datasetposted on 2021-04-29, 13:30 authored by Cathy SpillingCathy Spilling, Mohani-Preet Dhillon, Daniel Burrage, Sachelle Ruickbie, Emma Baker, Thomas Barrick, Paul Jones
Data supporting "Factors associated with brain damage in smoking-related diseases: Chronic Obstructive Pulmonary Disease (COPD) and coronary artery disease".
A zip archive is provided, containing the data as an excel file "COPD_&_CAD_data.xlsx" and and associated readme file "COPD_&_CAD_data_readme.txt.
The dataset comprises demographics and a range of biomedical variables from a cohort of 100 patients (53 patients with a primary diagnosis of Chronic Obstructive Pulmonary Disease (COPD), 24 with a primary diagnosis of coronary artery disease (CAD) and 23 with both COPD and CAD. Patients were recruited from respiratory and cardiology departments at St George's Hospital NHS Foundation Trust between December 2015 and October 2017. Variables include a range of markers of respiratory function, vascular risk, cardiovascular system, systemic inflammation, retinal microvascular pathology (from retinal photography) and structural brain damage (from brain magnetic resonance imaging).
Ethical approval was granted by the national research ethics committee London - Dulwich (16/LO/0547) and East Midlands - Leicester South Research Ethics Committee (15/EM/0425). All patients provided informed written consent.
Raw data is provided on Sheet 1 of the Excel file. Sheet 2 of the Excel file includes age and sex adjusted variables (residuals from linear regressions with age and sex entered as predictors). A number of variables had a non-Guassian distribution. These variables were transformed using log10 or square root transformations with or without first reflecting about the mean (indicated in variable names) prior to adjusting for age and sex.
Novel vascular complications of chronic obstructive pulmonary disease: a prospective clinical and imaging study to evaluate the effect of acute exacerbations of chronic obstructive pulmonary disease on cerebral small vessel disease and microvasculature.
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