Bactericidal and Sterilizing Activities of Antituberculosis Drugs during the First 14 Days (EBA Study)

Colony-forming units of Mycobacterium tuberculosis in sputum were drug activity that is deemed necessary by the Food and Drug counted at 2-day intervals in 100 patients treated with 22 regimens. Administration for licensing new antituberculosis drugs. of isoniazid, rifampin, pyrazinamide, ethambutol, or streptomycin, A major drawback of the EBA technique is that it does given alone or in combinations. The exponential fall in colony- not measure the sterilizing activity of a drug against bacilli that forming units was measured by linear regression coefficients of the persist despite effective drug treatment and are responsible for log counts during the initial 2-day phase of rapid, drug-determined prolonging the treatment period. The possibility of detecting killing and during the subsequent 12 days of much slower sterilizing the sterilizing activity of rifampin by prolonging the study activity. The regression coefficients during the first 2 days varied period beyond Day 2 (termed extended EBA) has been raised significantly according to the drug; the greatest effects in multiple (7, 8). These suggestive results need confirmation.