This COPD_&_CAD_data_readme.txt file was generated on 14/06/2022 by Dr Mohani Dhillon


GENERAL INFORMATION

1. Title of Dataset: Data supporting "White Matter Damage linked to Systemic Inflammation in COPD and Coronary Artery Disease". 

2. Author Information


	
	A. Co-investigator Contact Information
		Name: Dr Mohani-Preet K Dhillon
		Institution: St George's University of London
		Email: mdhillon@sgul.ac.uk

	B. Co-investigator Contact Information
		Name: Dr Catherine A Spilling
		Institution: St George's University of London
		Email: cspillin@sgul.ac.uk 
 
	C. Principal Investigator Contact Information
		Name: Dr Daniel R Burrage 
		Institution: St George's University of London
		Email: dburrage@sgul.ac.uk

	D. Co-investigator Contact Information
		Name: Dr Sachelle Ruickbie
		Institution: St George's University Hospitals NHS Foundation Trust
		Email: sachelle.ruickbie@nhs.net ‎ 

	E. Co-investigator Contact Information
		Name: Professor Emma H Baker
		Institution: St George's University of London
		Email: ebaker@sgul.ac.uk
 
	F. Co-investigator Contact Information
		Name: Dr Thomas R Barrick
		Institution: St George's University of London
		Email: tbarrick@sgul.ac.uk 

	G. Co-investigator Contact Information
		Name: Professor Paul W Jones
		Institution: St George's University of London
		Email: pjones@sgul.ac.uk 


3. Date of data collection: December 2015 to October 2017 

4. Geographic location of data collection: St George's University of London, UK 

5. Information about funding sources that supported the collection of the data: Data collection was supported by the National Institute for Health Research (NIHR) as part of DRB's doctoral research fellowship (grant number: DRF-2016-09-088) and by internal St George's University of London Research Funding provided to PWJ.


SHARING/ACCESS INFORMATION

1. Licenses/restrictions placed on the data: CC-BY 4.0 

2. Links to publications that cite or use the data: 

3. Links to other publicly accessible locations of the data: N/A

4. Links/relationships to ancillary data sets: N/A

5. Was data derived from another source? No
	
6. Recommended citation for this dataset: Dhillon M-PK, Spilling CA, Burrage DR, Ruickbie S, Baker EH, Barrick TR, Jones PW. White Matter Damage linked to Systemic Inflammation in COPD and Coronary Artery Disease. 2022.   


DATA & FILE OVERVIEW

1. File List: 
COPD_&_CAD_data.xlsx - Excel document containing raw data (sheet 1)
COPD_&_CAD_data_readme.txt - Explanatory text file 

2. Relationship between files, if important: N/A

3. Additional related data collected that was not included in the current data package: Data has been combined from two complementary studies (NoVasC2 and NoVasC3). Additional variables were collected as part of NoVasC 2 and NoVasC 3 studies, which were not relevant to the "White Matter Damage linked to Systemic Inflammation in COPD and Coronary Artery Disease" paper and are not included in this dataset. To ensure anonymity, age and sex have also been excluded from the data file and brain scans are not provided. 

4. Are there multiple versions of the dataset? no
	

METHODOLOGICAL INFORMATION

1. Description of methods used for collection/generation of data: 
<Include links or references to publications or other documentation containing experimental design or protocols used in data collection>

2. Methods for processing the data: 
Raw data is provided inn sheet 1. Variables which were non-normally distributed were transformed to approcimate Guassinity using log10 and square root transformation on raw data. 

3. Instrument- or software-specific information needed to interpret the data: Analysis was originally performed in SPSS v26.0

4. Standards and calibration information, if appropriate: N/A

5. Environmental/experimental conditions: data collected at St George's University of London at a single study visit.

6. Describe any quality-assurance procedures performed on the data: data was checked for transcription errors.

7. People involved with sample collection, processing, analysis and/or submission: M-PK Dhillon, C Spilling, DR Burrage, S Ruickbie, EH Baker, TR Barrick, PW Jones. 

DATA-SPECIFIC INFORMATION FOR: [FILENAME]
<repeat this section for each dataset, folder or file, as appropriate>

1. Number of variables: 15

2. Number of cases/rows: 100

3. Variable List:-

Sheet 1:
Patient Group (1 = COPD + CAD, 2 = CAD, 3 = COPD)
Smoking (1=current, 0=not current)
FEV1 % pred.
FVC % pred.
FEV1/FVC 
Oxygen Saturations (%)
Pack years smoking history
high-sensitivity C-Reactive Protein (mg/L)
Fibrinogen (g/L)
Neutrophil count x10^9/L
MoCA
White matter lesion volume
Median Fractional Anisotropy
Median Mean Diffusivity (mm^2s^-1)
 
 
4. Missing data codes: 999999 (missing)

5. Specialized formats or other abbreviations used: 
Abbreviations: CAD, Coronary Artery Disease, COPD, Chronic Obstructive Pulmonary Disease, FEV1, Forced Expiratory Volume in 1 second, Forced Vital Capacity, Montreal Cognitive Assessment, MoCA.